Eli Manning (notes) / New York Giants

Key stats: Manning threw two touchdown passes or more in 11 of 16 starts in 2010. But he threw two interceptions in half or more of the games for the Giants.

Skinny: Manning the past two seasons (8,023 yards, 58 touchdowns) were better than his fantasy football perspective. It has a strong cast, led by WR Hakeem Nicks (notes), an emerging big-play threat. However, if your league penalizes for sales, its stock suffered a major blow. Manning threw 25 picks and lost five fumbles in 2010.

Josh Freeman has not always put great big numbers.